Mind Blowing Food Facts

Started by CrackSmokeRepublican, March 11, 2012, 12:52:33 AM

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CrackSmokeRepublican

Mind Blowing Food Facts

Share Pineapple is a natural painkiller. The fruit contains anti-inflammatory enzymes that bring pain relief from conditions such as arthritis, according to a study at Reading University.

Pomegranate juice could prevent a heart attack. This wonder juice is believed to improve blood flow to the heart and lower blood pressure.

Onions are natural antibiotics. They might make your breath pong but onions contain allicin, a powerful antibiotic that also protects the circulatory system.

Mushrooms can ward off colds. They contain more of an immune-boosting antioxidant called ergothioneine than any other food, say researchers at Pennsylvania State University.

Blueberries can boost memory. A study at Tufts University in Boston showed eating half a cup of this fruit regularly could delay age-related deterioration in co-ordination and short-term memory.

A pint is as good as red wine. A pint of beer or stout is officially as beneficial as red wine for fighting cancer and heart disease, says scientists at Canada's University of Western Ontario.

Eat chocolate, live longer. Harvard University scientists say that eating a couple of chocolate bars a week could extend your life by almost a year.
Grapefruit juice can stop medicine working. If you're taking medication, avoid washing it down with grapefruit juice as there is evidence that it prevents some drugs being broken down.

You should never drink tea or coffee with meals. Tannins in tea and coffee prevent absorption of certain nutrients. A cup of tea with a meal will halve the iron you get from it, whereas a glass of orange juice will double it.

Cherries can cure gout. Cherries contain compounds that significantly reduce the chemicals in the body which cause joint inflammation.

Eating curry could help prevent Alzheimer's disease. According to a report in the Journal of Biological Chemistry, a yellow pigment used in curry, curcumin, can stop amyloid plaques in the brain that cause the condition.

Sniffing a lemon could help you beat asthma. Millions of asthmatics could find lemons ease their symptoms. Studies in rats found that breathing improved after they inhaled limonene, the chemical that gives lemons their smell.

Kiwi fruit can improve your eyesight. This fuzzy fruit is a surprisingly good source of lutein, an antioxidant that protects your vision.

Garlic can cure mouth ulcers and verrucas. Here's an old wives' tale that works: halve a clove of garlic, squeeze, and apply a drop of the juice to the offending growth at bedtime.

You can have too little salt. Too much salt isn't good for us but not getting enough can trigger low blood pressure in those susceptible. Consult your GP before making any major diet changes

Figs can delay brittle bone disease. Good news for the three million osteoporosis sufferers in the UK - it is possible to slow its progress by eating calcium-packed figs.

Soya can mimic breast cancer drugs. A team of Cambridge researchers discovered that a diet high in soya can have a similar effect to anti-cancer drug Tamoxifen

Barbecued food can cause cancer. Eating meat that's chargrilled or burnt could lead to stomach, pancreatic, colon and breast cancer because it creates high levels of carcinogenic compounds.

Cinnamon can help diabetics. Just half a teaspoon a day of this spice can significantly reduce blood sugar levels in diabetics, says US research.

Chillies can help you breath more easily. Capsaicin, which occurs in chillies, shrinks the mucous membranes which can ease blocked noses and sinuses.

Watermelon is good for the prostate. Men will be glad to know that the red flesh contains the antioxidant Lycopene, which helps keep the prostate gland healthy.

Coriander can lower your cholesterol levels. This aromatic herb can reduce cholesterol levels and prevent heart problems.

Nibbling nuts can prevent blood clots. Nuts boost nitric oxide, a compound that relaxes blood vessels and eases blood flow.

Banish bad breath with natural yoghurt. A few spoonfuls of natural yoghurt can neutralise halitosis, according to Japanese researchers.

Artificial sweeteners can make you fat. Research by US scientists shows that artificial sweeteners such as fructose change the body's metabolism, making it more likely you'll gain weight.

A caffeine hit can improve your love life. If your libido's flagging, try a quick shot of espresso. Research shows a daily cup of coffee boosts blood circulation to vital areas.

Honey combats ulcers. Manuka honey from New Zealand may be useful in preventing stomach ulcers, so have some in your morning porridge.

Olive oil can be as good for the heart as aspirin. There is evidence that the main compound in olive oil, oleocanthal, contains the same properties as painkillers used to treat heart conditions.

Boozing can help you stay slim. A recent study by US scientists discovered that women who enjoyed the "occasional" tipple were 27 per cent less likely than teetotallers to be obese.

Sesame seeds can lower blood pressure. Try sprinkling on salad to reduce your blood pressure. They're also an excellent source of protein and calcium, iron and niacin.

Eating avocados can cheer you up. These green fruits perk you up by boosting your serotonin levels, which can help to beat depression.

A daily cup of tea could reduce your risk of cancer. Tea contains lots of flavonoids, disease-fighting substances that lower blood pressure, fight cancer and even prevent wrinkles. One cup a day may halve your risk of liver cancer.

Rhubarb can relieve constipation. This red fruit, delicious in crumbles, contains a natural laxative.

Drinking green tea can prevent prickly heat. Green tea is not just an excellent antioxidant - sipping it can help you avoid a painful bout of prickly heat.

Pasta may aid sleep. Going to bed after eating carbohydrates can induce restful sleep. Complex carbs like whole wheat pasta and bread are most effective.

Semi-skimmed milk contains more calcium. Half-fat milk is not only lower in calories than full-fat, it also contains more calcium, protein and B vitamins. However it does contain less vitamin A and E.

Breakfast can reduce risk of throat cancer. According to scientists at Aberdeen University; eating breakfast reduces your risk of developing oesophageal cancer.

Eat ice cream for glossy hair. A few scoops can do wonders for your crowning glory due to ice cream's high levels of Vitamin B2.

Kidney beans help you look younger. The US Department of Agriculture ranked these as the third most antioxidant- rich food.

Flaxseed oil can help you stay trim. Drizzling this oil over salads and soups can trick the body into feeling full and storing less fat.

Spinach can make kidney stones worse. High-oxalate foods such as spinach encourage the formation of kidney stones, which occur when waste products in the urine crystallise.

Crusty bread may cut cancer. Crusts have eight times the amount of cancer-fighting antioxidants called pronyl-lysine than the rest of the bread, according to a study in the Journal of Agricultural and Food Chemistry.

Boiling hot drinks can ruin your smile. Drinking very hot fluids can cause your gums to recede, leaving them prone to infection. Allow drinks to cool before drinking.

Frozen vegetables are just as healthy as fresh. Although generally speaking fresh is best, providing the fruit or vegetables are frozen immediately after picking, they will retain most of their nutrients and vitamins.

Drinking fruit juice can rot your teeth. High fructose levels in fruit can cause tooth decay. Have them with meals or brush your teeth directly after drinking.

Fizzy drinks can lower your immunity. The tartrazine found in fizzy drinks causes depletion of the body's zinc levels. Zinc plays a vital role in supporting our immune systems - 15mg a day is the recommended daily amount.

Teabags can fight cold sores. Placing a cold, used teabag on a cold sore can reduce inflammation and infection.

http://www.knowledgebase-script.com/dem ... e-533.html
After the Revolution of 1905, the Czar had prudently prepared for further outbreaks by transferring some $400 million in cash to the New York banks, Chase, National City, Guaranty Trust, J.P.Morgan Co., and Hanover Trust. In 1914, these same banks bought the controlling number of shares in the newly organized Federal Reserve Bank of New York, paying for the stock with the Czar\'s sequestered funds. In November 1917,  Red Guards drove a truck to the Imperial Bank and removed the Romanoff gold and jewels. The gold was later shipped directly to Kuhn, Loeb Co. in New York.-- Curse of Canaan

CrackSmokeRepublican

Found this interesting. Looks like there is a sudden commercialization interest around this. --CSR

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July 19, 2011 08:00 AM Eastern Daylight Time
First International Congress on Ergothioneine Reveals Newly Rediscovered Antioxidant, Likely "Essential to Human Life"

Oxis International's Debut Gathering of Leading Researchers in Anti-Aging Medicine Discusses Merits of the Unparalleled Antioxidant, Ergothioneine

BEVERLY HILLS, Calif.--(BUSINESS WIRE)--An impressive "who's who" in anti-aging medicine and research from around the world gathered for the first time this past weekend to discuss the myriad benefits of L-ergothioneine, a newly rediscovered antioxidant that is 6,000 times more potent than Vitamin E. Oxis International () provided an educational grant in support of the First International Congress on Ergothioneine, which featured lively discussion and sharing of information on oxidative stress, healthy aging and chronic disease prevention and management. Attendees agreed that the key "takeaway" from the conference was that ergothioneine may well be a previously unidentified nutrient essential to human life, a completely unique substance that not only has extraordinary antioxidant activity but has also been shown to enhance and extend the potency of other antioxidants.

    "It is perhaps the most powerful and effective antioxidant ever, with unparalleled potential benefits for cognitive function, eye health, immune modulation, lung health, reproductive health, skin health and overall wellness at all stages of the aging process."

Experts are embracing the potential of this new discovery.

    Dr. Okezie Aruoma, M.B.A., Ph.D., D.Sc., Touro College of Pharmacy, New York and President of Oxis Advisory Board, says, "The uniqueness of ergothioneine in the human body may not only reside in its ability to protect organs against age-dependent degeneration due to chronic inflammation, but also increase the body's availability of glutathione, (the first line antioxidant defense in vivo,) while conserving Vitamin E, which is a critical process in detoxification."
    Dr. L. Stephen Coles, M.D. Ph.D., UCLA Department of Chemistry and Biochemistry, member of Oxis' "Blue Ribbon" Science Advisory Board, says that the potential for ergothioneine's impact on human health is exciting. "This small amino acid (containing a sulfur atom) is a critical molecule in many different biochemical pathways within the cell. It serves to protect the tissues against dangerous free radicals. Further, the human body has a unique gene that synthesizes a carrier protein whose role is to enable ergothioneine to be transported into the cells."
    Dr. Bruce Ames, Ph.D., Children's Hospital, Oakland Research Institute, member of the National Academy of Sciences and inventor of the "Ames Test," states, "Ergothioneine is an old compound that new research is suggesting may be an unappreciated vitamin. It is specifically transported into the body and humans do not make it." Dr. Ames was presented with a special "Achievement Award" at the conference, in recognition of a lifetime of extraordinary achievements in antioxidants and anti-aging research.
    Dr John Repine, M.D., Web Waring Institute, University of Colorado, also a member of Oxis' Advisory Board, was awarded a $1.34M grant from the US Department of Defense that is, in part, providing funding to continue his research efforts on the potential use of L-ergothioneine as a therapeutic intervention for Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS,) severe lung diseases that can be fatal in combat veterans and other trauma patients.

Discovered by a French scientist in 1909, ergothioneine has been dormant for over 100 years until now. Leading scientists now believe it is a nutrient essential to human life, but, unlike any other compound, it cannot be made by the human body or by plants and has a gene (SLC22A4) and transporter (ETT) dedicated only to it. It is an amino acid with a unique structure naturally produced by microorganisms that exist in soil, and only found in very small quantities in certain exotic mushrooms, oat bran, beans and a few other foods. Oxis International, a leading biotechnology company, owns the patent to manufacture pure l-ergothioneine. Oxis has now begun to market the ingredient in consumer products, combining ergothioneine with other compounds to create products for joint health and aging support, among others.

"L-ergothioneine may be the most important nutritional breakthrough in years," says Bernie Landes, President of Oxis International. "It is perhaps the most powerful and effective antioxidant ever, with unparalleled potential benefits for cognitive function, eye health, immune modulation, lung health, reproductive health, skin health and overall wellness at all stages of the aging process."

About OXIS International, Inc.


OXIS International, Inc. is a long-established, but recently revitalized biotechnology Company developing multiple proprietary, natural substance-based products focused on oxidative stress and inflammation, which are associated with the negative effects of free radicals and reactive oxygen species (ROS). The Company's consumer product portfolio is quickly expanding to include dietary supplements, functional foods and beverages, skin care and other personal care products, and animal health products. Specifically, Oxis is emphasizing the unique properties of L-Ergothioneine (ERGO), a highly potent, patent-protected and versatile antioxidant. The Company recently signed a strategic financing agreement with its primary product development and manufacturing partner, Gemini Pharmaceuticals, launched its first product, ErgoFlex, for joint pain relief and overall joint health and announced a joint venture with engage:BDR for a global leader in online sales and marketing.

For more information, please visit http://www.oxis.com.

Photos/Multimedia Gallery Available: http://www.businesswire.com/cgi-bin/mmg ... 63&lang=en

http://www.businesswire.com/news/home/2 ... ntioxidant
After the Revolution of 1905, the Czar had prudently prepared for further outbreaks by transferring some $400 million in cash to the New York banks, Chase, National City, Guaranty Trust, J.P.Morgan Co., and Hanover Trust. In 1914, these same banks bought the controlling number of shares in the newly organized Federal Reserve Bank of New York, paying for the stock with the Czar\'s sequestered funds. In November 1917,  Red Guards drove a truck to the Imperial Bank and removed the Romanoff gold and jewels. The gold was later shipped directly to Kuhn, Loeb Co. in New York.-- Curse of Canaan

CrackSmokeRepublican

QuoteBoozing can help you stay slim. A recent study by US scientists discovered that women who enjoyed the "occasional" tipple were 27 per cent less likely than teetotallers to be obese.

At fighting strength... but God knows... I've been boozing.... -God D*amn the J*ws... for their Godless Scams... -CSR
After the Revolution of 1905, the Czar had prudently prepared for further outbreaks by transferring some $400 million in cash to the New York banks, Chase, National City, Guaranty Trust, J.P.Morgan Co., and Hanover Trust. In 1914, these same banks bought the controlling number of shares in the newly organized Federal Reserve Bank of New York, paying for the stock with the Czar\'s sequestered funds. In November 1917,  Red Guards drove a truck to the Imperial Bank and removed the Romanoff gold and jewels. The gold was later shipped directly to Kuhn, Loeb Co. in New York.-- Curse of Canaan

Christopher Marlowe

QuoteIt is an amino acid with a unique structure naturally produced by microorganisms that exist in soil, and only found in very small quantities in certain exotic mushrooms, oat bran, beans and a few other foods.
Now I am doubly thankful that I have been adding oat bran to my morning smoothies.
And, as their wealth increaseth, so inclose
    Infinite riches in a little room

CrackSmokeRepublican

Some evidence that Mushrooms like this might help with Alzheimer's(?).

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Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death.

by Jung-Hee Jang, Okezie I Aruoma, Ling-Sun Jen, Hae Young Chung, Young-Joon Surh
Abstract

Beta-amyloid (Abeta) peptide is the major component of senile plaques and considered to have a causal role in the development and progression of Alzheimer's disease. There has been compelling evidence that Abeta-induced cytotoxicity is mediated through oxidative and/or nitrosative stress. Recently, considerable attention has been focused on dietary manipulation of oxidative and/or nitrosative damage. l-Ergothioneine (EGT; 2-mercaptohistidine trimethylbetaine) is a low-molecular-weight naturally occurring thiol compound of dietary origin that exists in the brain, liver, kidney, erythrocytes, ocular tissues, and seminal fluids of mammals. This water-soluble antioxidant has the ability to scavenge hydroxyl and peroxynitrite radicals as well as activated oxygen species, such as singlet oxygen. In this study, we investigated the effects of EGT on Abeta-induced oxidative and/or nitrosative cell death. Rat pheochromocytoma (PC12) cells treated with Abeta underwent apoptotic death as determined by positive in situ terminal end-labeling (TUNEL staining), decreased mitochondrial transmembrane potential, increased ratio of proapoptotic Bax to antiapoptotic Bcl-XL, elevated caspase-3 activity, and cleavage of poly(ADP-ribose) polymerase. EGT pretreatment attenuated Abeta-induced apoptosis in PC12 cells. Compared to N-acetyl-l-cysteine, which mainly scavenges reactive oxygen species, EGT effectively inhibited Abeta-induced cell death by suppressing peroxynitrite formation and subsequent nitration of protein tyrosine residues. The effects of EGT on the cytotoxicity induced by the nitric oxide donor sodium nitroprusside (SNP) and the peroxynitrite-generating 3-morpholinosydnonimine chlorhydrate (SIN-1) were compared. Whereas EGT significantly protected against SIN-1-mediated cell death, it barely affected the cytotoxicity induced by SNP. Thus EGT may attenuate apoptosis caused by Abeta, preferentially by eliminating peroxynitrite derived from the neurotoxic peptide. The importance of diet-derived antioxidants in the management of Alzheimer's disease and other neurodegenerative disorders is discussed.

http://www.mendeley.com/research/ergoth ... tic-death/


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A lot of weight lifting "Pre-workout Formulas" contain NO.  Looks like Pot may help Alzheimer's via Apocynin... keep in mind that "Wheat" causes inflammation which can lead to Alzheimer's...especially with people infected with Herpes Simplex Virus 1...    -- CSR

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Nitric Oxide Modulates Superoxide Release and Peroxynitrite Formation in Human Blood Vessels

    Tomasz J. Guzik,
    Nick E.J. West,
    Ravi Pillai,
    David P. Taggart,
    Keith M. Channon



Abstract

Nitric oxide and superoxide have important roles as vascular signaling molecules. Nitric oxide (NO) reacts rapidly with superoxide, producing peroxynitrite. The relative balance between these radicals has important implications for vascular pathophysiology in hypertension and other vascular disease states. However, the relationships between superoxide, NO, and peroxynitrite formation in human blood vessels remain unclear. Accordingly, we systematically measured NO, superoxide, and peroxynitrite production from human internal mammary arteries, radial arteries, and saphenous veins from 78 patients undergoing coronary bypass surgery. Basal superoxide release was detected in all vessels at similar levels. However, endothelial removal or nitric oxide synthase inhibition increased mean superoxide release, with a corresponding reduction in peroxynitrite formation. Conversely, NO donors and superoxide scavengers both reduced superoxide release, whereas only NO donors increased peroxynitrite formation. These changes were much larger in arteries that in veins, but there were striking correlations between superoxide production, NO bioavailability, and peroxynitrite formation between the vessel types. Our findings provide direct evidence for coordinated vascular signaling mediated by interactions between NO, superoxide, and peroxynitrite and have important implications for studies of the functional effects of these radicals in human blood vessels.

The superoxide anion (OO−) is a reactive oxygen species produced by cellular oxidases in the vascular wall, which reacts rapidly with nitric oxide (NO), producing peroxynitrite.1 The reaction between NO and superoxide occurs at almost diffusion-limited rate, 6 times greater than the removal of superoxide by copper-zinc superoxide dismutase (Cu/Zn SOD). The interaction between NO and superoxide depletes NO bioactivity and is functionally important because NO is a pivotal mediator of key vascular functions, including regulation of smooth muscle tone and blood pressure, platelet activation, and vascular cell signaling.2 Consequently, the loss of NO bioactivity associated with increased vascular superoxide plays a potentially important role in the pathogenesis of endothelial dysfunction associated with conditions such as hypertension3 and atherosclerosis.4– 6 In addition to the effects mediated by NO scavenging, increasing evidence suggests additional roles for superoxide–nitric oxide interactions in the modulation of vascular signaling through redox-sensitive mechanisms.7 Furthermore, peroxynitrite (ONOO−), formed by the NO-superoxide reaction, has additional detrimental effects on vascular function, by oxidation of cellular proteins and lipids, low-density lipoprotein (LDL) particles,8 or direct cell toxicity.9 However, the formation of peroxynitrite may also generate nitrosylated thiols that function as endogenous NO donors that can induce vasorelaxation10 and inhibit platelet aggregation.11

Taken together, these observations from in vitro studies and animal models suggest that the relative balance between NO and superoxide production and the formation of peroxynitrite determines the roles of the individual radicals in the regulation of vascular function in hypertension and vascular disease states. In human vessels, recent studies have shown that reduced NO-mediated vasorelaxations in arteries and veins from patients with vascular disease risk factors is associated with increased superoxide production.12,13 However, whether this association is due to direct NO-superoxide scavenging with peroxynitrite formation and how these interactions modulate the respective bioactivities of the individual radicals in human blood vessels are unclear. Accordingly, we sought to systematically evaluate the relationships and interactions between superoxide production, NO bioavailability, and peroxynitrite formation in human arteries and veins from patients with vascular disease.

http://hyper.ahajournals.org/content/39/6/1088.full

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Apocynin

Apocynin, also known as acetovanillone, is a natural organic compound structurally related to vanillin. It has been isolated from a variety of plant sources and is being studied for its variety of pharmacological properties.
Contents

 History

Apocynin was first described by Oswald Schmiedeberg, a German pharmacologist, in 1883 and was first isolated from the root of Canadian hemp (Apocynum cannabinum). At the time, this plant was already used for its known effectiveness against edema and heart problems. In 1971, apocynin was also isolated from Picrorhiza kurroa, a small plant that grows at high altitudes in the western Himalayas. P. kurroa was used for ages as a treatment for liver and heart problems, jaundice, and asthma. In 1990, Simons et al. isolated apocynin to a pharmacologically useful level using an actively guided isolation procedure. Apocynin's observed anti-inflammatory capabilities proved to be a result of its ability to selectively prevent the formation of free radicals, oxygen ions, and peroxides in the body. Apocynin has since been extensively studied to help determine its disease-fighting capabilities and applications.

 Physical properties

Apocynin is a solid with a melting point of 115 °C and the faint odor of vanilla. It is soluble in hot water, alcohol, benzene, chloroform, and ether.

Mode of action

NADPH oxidase is an enzyme that effectively reduces O2 to superoxide (O2–•), which can be used by the immune system to kill bacteria and fungi. Apocynin is an inhibitor of NADPH oxidase activity and thus is effective in preventing the production of the superoxide in human white blood cells or neutrophilic granulocytes. It does not however obstruct the phagocytic or other defense roles of granulocytes. Due to the selectivity of its inhibition, apocynin can be widely used as an inhibitor of NADPH oxidase without interfering in other aspects of the immune system.

Apocynin was used to determine whether ionic activation due to proton flux across the membrane of renal medulla cells was coupled to NADPH oxidase production of superoxide. Apocynin was introduced to the cells and completely blocked the production of superoxide, and was a key component in determining that the proton outflow was responsible for the activation of NADPH oxidase.[1]

Potential use in medical treatments

    Anti-arthritic: Neutrophils are a key component of the pathogenesis of collagen induced arthritis and in the mechanisms that lead to the start of inflammation of the joints. The action of apocynin reduces the presence of such cells before the inflammation has begun but it is unable to reverse inflammation that is already present.[2]
    Bowel disease: Apocynin treatment in rats has been proven to lessen damage in the colon as well as the enzymatic activity of myeloperoxidase which is associated with inflammation. In addition, apocynin also decreased the number of macrophages and polymorphonuclear leukocytes in the colon.[3]
    Anti-asthmatic: The glucoside of apocynin, androsen, is being investigated for the treatment of asthma for has been shown to prevent bronchial obstruction in guinea pigs. It is believed that the anti-asthmatic quality of apocynin comes from its interference with certain inflammatory processes.[4]
    Atherosclerosis: Apocynin is used in the treatment of atherosclerosis in order to prevent the activity of NADPH oxidase activity, halting the production of reactive oxidative species. In effect, this inhibition stops initiation of disease in the endothelial cells.[5]
    Familial ALS: Apocynin extended the lives of mutant mice and reduced glial cell toxicity of cultured cells lines with a defective Superoxide Dismutase-1 (SOD1) gene -- a genetic defect found in some people with hereditary amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease). Researchers believe the benefit derives from a newly discovered role for SOD1 as a self-regulating redox sensor for NADPH oxidase-derived O2• production. The findings in mice may point to new drug targets for hereditary ALS.[6]
After the Revolution of 1905, the Czar had prudently prepared for further outbreaks by transferring some $400 million in cash to the New York banks, Chase, National City, Guaranty Trust, J.P.Morgan Co., and Hanover Trust. In 1914, these same banks bought the controlling number of shares in the newly organized Federal Reserve Bank of New York, paying for the stock with the Czar\'s sequestered funds. In November 1917,  Red Guards drove a truck to the Imperial Bank and removed the Romanoff gold and jewels. The gold was later shipped directly to Kuhn, Loeb Co. in New York.-- Curse of Canaan

CrackSmokeRepublican

Contact: Dan Page
http://www.npistat.com/adrc/Treatment.asp.

"The prospect of finding a safe and effective new approach to both prevention and treatment of Alzheimer's disease is tremendously exciting," said principal investigator Gregory Cole. He is professor of medicine and neurology at the David Geffen School of Medicine at UCLA, associate director of the UCLA Alzheimer's Disease Research Center, and associate director of the Geriatric Research, Education and Clinical Center at the VA Greater Los Angeles Healthcare System at Sepulveda, Calif.

"Curcumin has been used for thousands of years as a safe anti-inflammatory in a variety of ailments as part of Indian traditional medicine," Cole said. "Recent successful studies in animal models support a growing interest in its possible use for diseases of aging involving oxidative damage and inflammation like Alzheimer's, cancer and heart disease. What we really need, however, are clinical trials to establish safe and effective doses in aging patients."

The research was funded by the Siegel Life Foundation, Veterans Affairs, Alzheimer's Association, UCLA Alzheimer's Disease Research Center and private donors.

Alzheimer's disease (AD) is an irreversible, progressive brain disorder that occurs gradually and results in memory loss, unusual behavior, personality changes, and a decline in thinking abilities. These losses relate to the death of brain cells and the breakdown of the connections between them.

The disease is the most common form of dementing illness among middle and older adults, affecting more than 4 million Americans and many millions worldwide. The prevalence of Alzheimer's among adults ages 70-79 in India, however, is 4.4 times less than the rate in the United States.

Widely used as a food dye and preservative, and in some cancer treatments, curcumin has undergone extensive toxicological testing in animals. It also is used extensively in traditional Indian medicine to treat a variety of ailments.

Other members of the research team are Fusheng Yang, Giselle Lim, Aynun Begum, Mychica Simmons, Suren Ambegaokar, Ping Ping Chen of UCLA; Rakez Kyad and Charlie Glabe of the University of California at Irvine; and Sally Frautschy of UCLA and the Greater Los Angeles VA Healthcare System at Sepulveda.

The Alzheimer Disease Research Center at UCLA, directed by Dr. Jeffrey L. Cummings, was established in 1991 by a grant from the National Institute on Aging. Together with grants from the Alzheimer's Disease Research Center of California and the Sidell-Kagan Foundation, the center provides a mechanism for integrating, coordinating and supporting new and ongoing research by established investigators in Alzheimer's disease and aging.

Veterans Affairs Greater Los Angeles Health Care System and Sepulveda Ambulatory Care Center combine resources to form a unified Geriatric Research Education and Clinical Center, one of 20 nationwide. These centers of excellence are designed to improve health care and quality of life to older veterans through the advancement and integration of research, education and clinical achievements in geriatrics and gerontology into the total VA health care system and broader communities.

A copy of the full paper can be found on the Journal of Biological Chemistry Web site at http://www.jbc.org/cgi/content/abstract ... RSTINDEX=0.

###

Additional online resources:
David Geffen School of Medicine at UCLA: http://www.medsch.ucla.edu/
UCLA Alzheimer's Disease Research Center: http://www.adc.ucla.edu/
VA Geriatric Research, Education and Clinical Center: http://www.grecc-gla.org/mission.htm

http://www.eurekalert.org/pub_releases/ ... 122804.php
After the Revolution of 1905, the Czar had prudently prepared for further outbreaks by transferring some $400 million in cash to the New York banks, Chase, National City, Guaranty Trust, J.P.Morgan Co., and Hanover Trust. In 1914, these same banks bought the controlling number of shares in the newly organized Federal Reserve Bank of New York, paying for the stock with the Czar\'s sequestered funds. In November 1917,  Red Guards drove a truck to the Imperial Bank and removed the Romanoff gold and jewels. The gold was later shipped directly to Kuhn, Loeb Co. in New York.-- Curse of Canaan