Recent Scottish Cancer Discoveries

[CrackSmokeRepublican]

29 December 2009

Scientists discover how wild mushroom cancer drug works

Cordyceps militaris growing on a moth pupa

The drug was first isolated from a parasitic mushroom

Scientists have discovered how a promising cancer drug, first discovered in a wild mushroom, works.

The University of Nottingham team believe their work could help make the drug more effective, and useful for treating a wider range of cancers.

Cordycepin, commonly used in Chinese medicine, was originally extracted from a rare kind of parasitic mushroom that grows on caterpillars.

The study will appear in the Journal of Biological Chemistry.

The cordyceps mushroom has been studied by medical researchers for some time - the first scientific publication on cordycepin was in 1950.

However, although the drug showed great promise, it was quickly degraded in the body.

It can be given with another drug to combat this - but the second drug can produce side effects that limit its potential use.

As a result, researchers turned their interest to other potential candidate drugs, and exactly how cordycepin worked on the body's cells remained unclear.
   
It could lay the groundwork for the design of new cancer drugs that work on the same principle.

Researcher Dr Cornelia de Moor said: "Our discovery will open up the possibility of investigating the range of different cancers that could be treated with cordycepin.

"It will be possible to predict what types of cancers might be sensitive and what other cancer drugs it may effectively combine with.

"It could also lay the groundwork for the design of new cancer drugs that work on the same principle."

The researchers have also developed a method to test how effective the drug is in new preparations, and combinations with other drugs, which might solve the problem of degradation more satisfactorily.

Dr De Moor said: "This is a great advantage as it will allow us to rule out any non-runners before anyone considers testing them in animals."

The Nottingham team observed two effects on the cells - at a low dose cordycepin inhibits the uncontrolled growth and division of the cells, and at high doses it stops cells from sticking together, which also inhibits growth.
   
The knowledge generated by this research demonstrates the mechanisms of drug action and could have an impact on one of the most important challenges to health


Both of these effects probably have the same underlying mechanism - that cordycepin interferes with how cells make proteins.

At low doses cordycepin interferes with the production of mRNA, the molecule that gives instructions on how to assemble a protein.

And at higher doses it has a direct impact on the making of proteins.

Professor Janet Allen is director of research at the Biotechnology and Biological Sciences Research Council, which funded the study.

She said: "This project shows that we can always return to asking questions about the fundamental biology of something in order to refine the solution or resolve unanswered questions.

"The knowledge generated by this research demonstrates the mechanisms of drug action and could have an impact on one of the most important challenges to health."

http://news.bbc.co.uk/2/hi/health/8428340.stm

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Scientists make cancer cells vanish

    * Cancer Research UK said results were encouraging

EXCLUSIVE: Helen Puttick, Health Correspondent


21 Apr 2010

Scottish scientists have made cancer tumours vanish within 10 days by sending DNA to seek and destroy the cells.

The system, developed at Strathclyde and Glasgow universities, is being hailed as a breakthrough because it appears to eradicate tumours without causing harmful side-effects. A leading medical journal has described the results so far as remarkable, while Cancer Research UK said they were encouraging.

Dr Christine Dufes, a lecturer at the Strathclyde Institute of Pharmacy and Biomedical Sciences and leader of the research, said: "The tumours were completely gone within 10 days. It is fantastic. When you talk about 10 days that is the time frame for curing a cold. Imagine if within 10 days you could completely make a tumour disappear."

Researchers around the world are trying to find ways to use genes as a cancer treatment, but one problem is ensuring they attack the tumour without destroying healthy tissue.

In laboratory experiments the Strathclyde research team used a plasma protein called transferrin, which carries iron through the blood, to deliver the therapeutic DNA to the right spot. Once in situ the DNA produced a protein that attacked the tumour cells.

The findings have been published in the Journal of Controlled Release, with an accompanying comment from editor Professor Kinam Park, of Purdue University, Indiana, saying other attempts to target genes at cancer cells have "seldom shown complete disappearance of tumours".

The research was initially supported with a grant from charity Tenovus Scotland, which supports the work of young scientists to help their ideas get off the ground.

http://www.heraldscotland.com/news/heal ... -1.1022114