Omicron : A Bridge Too Far ?

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p.27 inside 20211215_commissie_vws_briefing_presentatie_jaap_van_dissel.pdf

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https://rmstock.files.wordpress.com/2021/12/20211215_commissie_vws_briefing_presentatie_jaap_van_dissel.pdf
Chief of Dutch CDC (RIVM) present first findings on Omicron :
Powerpoint Presentatie Dhr. van Dissel wednesday 15 december 2021

The SARS-CoV-2 Omicron VoC (Variant of Concern) was found in South
Africa and arrived early in the afternoon on schedule in the
Netherlands on Sunday, November 28, 2021 :



A couple of days later Mike Adams held a interview with Silicon Valley
Tycoon Steve Kirsch, inventor of the Optical Mouse, founder of Mouse
Systems Corporation (MSC), and a whole train of several startup
pioneering companies like Frame Technology Corp., Infoseek and OneID,
They discuss corona and why he decided to spend 100% of his time on the
current health crisis. Strangely enough for such a pioneering and
visionary mind he somehow fails to see what this corona pandemic is
all about, so he decided to get himself jabbed ... two times .....
Halfway the interview omicron is discussed. when Mike Adams announces
breaking news that the first omicron infected person has arrived in 
California at LAX from South Africa.

Mike Adams interviews Steve Kirsch
Dec 4, 2021, 21:56 p.m. CET+0100
https://www.brighteon.com/88eab39c-9cb4-494f-9ea1-21311dea01aa
Steve Kirsch's newsletter | Substack
https://stevekirsch.substack.com/

Some time passes by and a week later David Icke has seen the
light in the omicron tunnel and figures it out, with the
help of his favorite Virologist Dr. Andrew Kaufman :

The `Omicron' testing scam and how it works to give the illusion of more cases
Posted on 10 December 2021
https://davidicke.com/2021/12/10/the-omicron-testing-scam-and-how-it-works-to-give-the-illusion-of-more-cases-david-ickes-dot-connect-the-news-show-on-ickonic/

Kaufman's brilliant analysis was however already done on Sunday,
November 28, 2021 in an interview with Sayer Ji, a health geek
and wizard who fully subscribes and underwrites Kaufman's thesis and
Statement On Virus Isolation (SOVI) : "The SARS-CoV2 virus does not
exist." :

New COVID 'Scariant': Fact or Fiction with Dr. Kaufman
Nov 29, 2021, 13:54 p.m. CET+0100,
https://rumble.com/vqx0i0-new-covid-scariant-fact-or-fiction-with-dr.-kaufman.html

The interview was made on Monday, Nov 29, 2021. A check at the genome
database gisaid.org on Friday, Dec 17, 2021, reveals that a total of
6,168,680 hCoV-19 genome sequences submissions are reported :



Which means that in just 18 days, (see video at 00:14:56) :



a total of 633,277 additional hCoV-19 genome sequence submissions were
reported. This poses the hypothesis that the COVID-19 pandemic is
foremost a `in silico' phenomenon. At [00:23:20] :



the gist of the omicron matter is presented :

   According the WHO: "A SARS-CoV-2 VoC (Variant Of Concern) has :
   - increase in transmissibility or detrimental change in COVID-19
     epidemiology; OR
   - increase in virulence or change in clinical disease presentation; OR
   - decrease in effectiveness of public health and social measures or
     available diagnostics, vaccines, therapeutics"

   "Preliminary evidence suggests an increased risk of reinfection with
    this variant, as compared to other VOCs. The number of cases of this
    [omicron] variant appears to be increasing in almost all provinces in
    South Africa. Current SARS-CoV-2 PCR diagnostics continue to detect
    this variant. Several labs have indicated that for one widely used PCR
    test, one of the three genes is not detected (called S gene dropout or
    S gene target failure) and this test can therefore be used as marker
    for this variant pending sequence confirmation"

SARS-CoV-2 (Wuhan) detection requires three genes to be present for a
positive result. SARS-CoV-2 (Omicron) only requires two genes to be
present for a positive result. This means that case numbers for testing
positive for Omicron will in general always be higher, by a rough shot
factor of 3/2 which is 1.5 times higher.
Then on Friday, December 17, the final nail in the omicron Variant of
Concern Coffin is hammered down :

  "According to the New York Times' coronavirus tracker, which
   averages the cases over the last week state by state, New York is
   reporting a daily average of 11,482 cases — the most in the nation
   — or 59 per 100,000. That reflects a 56 percent increase over the
   last two weeks. "
-- https://www.breitbart.com/politics/2021/12/17/new-york-reports-highest-daily-coronavirus-case-rate-despite-vaccine-mask-mandates/

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Tucker Carlson Tonight 12/20/21 FULL | Breaking Fox News December 20, 2021
2,367 views • Dec 20, 2021 • 34 likes 0 DISLIKE
Bekir Hançer • 151K subscribers
https://www.youtube.com/watch?v=0ZdQAYJEKXs

Download:
https://crashrecovery.org/daily/20.12.2021/Tucker%20Carlson%20Tonight%2012_20_21%20FULL%20_%20Breaking%20Fox%20News%20December%2020,%202021-0ZdQAYJEKXs.mp4

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The Chief Scientist of the Dutch CDC (RIVM) created a magnification of
the Omicron VoC :



mentioning that the Omicron RDB has at least 15 mutations. Searching
for `SARS-CoV-2 RBD` we find that :

   RBD : receptor-binding domain (RBD) of the spike protein (S protein)

A review article is found :

Antibodies and Vaccines Target RBD of SARS-CoV-2
Long Min  1 , Qiu Sun  1
Affiliations  expand
PMID: 33968996  PMCID: PMC8100443  DOI: 10.3389/fmolb.2021.671633
https://pubmed.ncbi.nlm.nih.gov/33968996/

REVIEW article
Front. Mol. Biosci., 22 April 2021 | https://doi.org/10.3389/fmolb.2021.671633
Antibodies and Vaccines Target RBD of SARS-CoV-2
Long Min and Qiu Sun*
https://www.frontiersin.org/articles/10.3389/fmolb.2021.671633/full
https://fjfsdata01prod.blob.core.windows.net/articles/files/671633/pubmed-zip/.versions/1/.package-entries/fmolb-08-671633/fmolb-08-671633.pdf
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https://rmstock.files.wordpress.com/2021/12/fmolb-08-671633.pdf

When downloading this article pdf, its interesting to see that Microsoft
through windows.net keeps track of all articles published on frontiersin.org :

   Registry Registrant ID:
   Registrant Name: Domain Administrator
   Registrant Organization: Microsoft Corporation
   Registrant Street: One Microsoft Way,
   Registrant City: Redmond
   Registrant State/Province: WA
   Registrant Postal Code: 98052
   Registrant Country: US
   Registrant Phone: +1.4258828080
   Registrant Phone Ext:
   Registrant Fax: +1.4259367329
   Registrant Fax Ext:
   Registrant Email: domains@microsoft.com

So what is the impact of Omicron on all of this ? Searching for
`Omicron RBD-TARGETING ANTIBODIES' we find a news-medical.net popular
magazine article :

Impact of SARS-CoV-2 Omicron mutations on the use of therapeutic antibodies in COVID-19 treatment
By Susha Cheriyedath, M.Sc.Dec 17 2021
Reviewed by Danielle Ellis, B.Sc.
https://www.news-medical.net/news/20211217/Impact-of-SARS-CoV-2-Omicron-mutations-on-the-use-of-therapeutic-antibodies-in-COVID-19-treatment.aspx
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https://rmstock.files.wordpress.com/2021/12/impact-of-sars-cov-2-omicron-mutations-on-the-use-of-therapeutic-antibodies-in-covid-19-treatment.pdf

Which makes reference of a fresh pre-print biorxiv article ;

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
Cameroni, Corti et.al.
doi: https://doi.org/10.1101/2021.12.12.472269
https://www.biorxiv.org/content/10.1101/2021.12.12.472269v1
https://www.biorxiv.org/content/10.1101/2021.12.12.472269v1.full.pdf
[pdf]https://rmstock.files.wordpress.com/2021/12/2021.12.12.472269v1.full_.pdf[/pdf]
https://rmstock.files.wordpress.com/2021/12/2021.12.12.472269v1.full_.pdf

According Cameroni, Corti et.al., we now have, what they call, a so-called :
"Omicron-mediated immune evasion". That does not sound very promising,
where the Authors and/or Editors somehow omit and/or removed Omicron
from the list of keywords mentioned inside this scientific publication :

   Keywords: SARS-CoV-2; COVID-19; antibody, vaccine, neutralizing antibodies;
             immune evasion

On the webpage of bioRxiv it is stated :

   Competing Interest Statement

   E.C., K.C., C.S., D.P., F.Z., A.D.M., A.L., L.P., M.S.P., D.C., H.K.,
   J.N., N.F., J.diI., L.E.R., N.C., C.H.D., K.R.S., J.R.D., A.E.P., A.C.,
   C.M., L.Y., D.S., L.S., L.A.P., C.H., A.T., H.W.V. and G.S. are
   employees of Vir Biotechnology Inc. and may hold shares in Vir
   Biotechnology Inc. L.A.P. is a former employee and shareholder in
   Regeneron Pharmaceuticals. Regeneron provided no funding for this work.
   The Veesler laboratory has received a sponsored research agreement from
   Vir Biotechnology Inc. HYC reported consulting with Ellume, Pfizer, The
   Bill and Melinda Gates Foundation, Glaxo Smith Kline, and Merck. She
   has received research funding from Emergent Ventures, Gates Ventures,
   Sanofi Pasteur, The Bill and Melinda Gates Foundation, and support and
   reagents from Ellume and Cepheid outside of the submitted work. The
   remaining authors declare that the research was conducted in the
   absence of any commercial or financial relationships that could be
   construed as a potential conflict of interest.

   

Which suggests that Big Pharma is involved in this study, amongst
others, and supported through the Chan Zuckerberg Initiative LLC.
philanthropy. The Corona health crisis is becoming more and more some
sort of a LHC CERN Project in complexity, where much needed independent
research on the matter seems to have gone extinct.

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With Omicron, Antibodies and Vaccines that Target the RBD of this
SARS-CoV-2 Variant of Concern (VoC) are out of luck. According
Cameroni, Corti et.al.,:

  "Most (26 out of 29) receptor-binding motif (RBM)-directed
   monoclonal antibodies (mAbs) lost in vitro neutralizing activity
   against Omicron."

where (RBM) receptor-binding motif is the RBD subdomain directly
interacting with the host receptor, ACE2.

  "Only three mAbs, including the ACE2-mimicking S2K146 mAb1,
   retaining unaltered potency. Furthermore, a fraction of broadly
   neutralizing sarbecovirus mAbs recognizing antigenic sites outside
   the RBM, including sotrovimab2, S2X2593 and S2H974, neutralized
   Omicron."

So if you want a catch all approach, according Cameroni, Corti et.al.,
sotrovimab will do the job, with or without Omicron in your body :

Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab
Anil Gupta, et.al.
N Engl J Med 385, 1941-1950, doi:10.1056/NEJMoa2107934 (2021).
https://doi.org/10.1056/NEJMoa2107934
https://www.nejm.org/doi/10.1056/NEJMoa2107934
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2107934?articleTools=true
[pdf]https://rmstock.files.wordpress.com/2021/12/nejmoa2107934.pdf[/pdf]
https://rmstock.files.wordpress.com/2021/12/nejmoa2107934.pdf

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[pdf]https://rmstock.files.wordpress.com/2022/01/fda-restricts-use-of-2-monoclonal-antibody-treatments.pdf[/pdf]
https://rmstock.files.wordpress.com/2022/01/fda-restricts-use-of-2-monoclonal-antibody-treatments.pdf